|
|
L-proline + NADP+ <=> L-pyrroline-5-carboxylate + NADPH + H+
|
1.5.1.2
pyrroline-5-carboxylate reductase
|
–
|
BMK
|
|
BRENDA:
BR36895
KEGG:
R01251
MetaCyc:
PYRROLINECARBREDUCT-RXN
SABIO-RK:
1470
|
|
|
|
L-proline + NAD+ <=> L-pyrroline-5-carboxylate + NADH + H+
|
1.2.1.88
L-glutamate gamma-semialdehyde dehydrogenase
1.5.1.2
pyrroline-5-carboxylate reductase
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
1.5.5.2
proline dehydrogenase
|
–
–
–
–
|
K
|
|
BRENDA:
BR36895-a;
BS439688
KEGG:
R01248
MetaCyc:
PYRROLINECARBREDUCT-RXN_WOP
SABIO-RK:
1468
|
|
|
|
L-arginine + 2-oxoglutarate + O2 <=> L-pyrroline-5-carboxylate + guanidine + succinate + CO2 + H2O + H+
|
1.14.20.7
2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
|
–
|
M
|
|
BRENDA:
BR49800
KEGG:
R09785
MetaCyc:
RXN-13396
|
|
|
|
H+ + L-pyrroline-5-carboxylate + malonyl-CoA + H2O <=> (2S,5S)-5-carboxymethylproline + CoA + CO2
|
2.3.1.226
carboxymethylproline synthase
|
–
|
BMK
|
|
BRENDA:
BR50641
KEGG:
R10485
MetaCyc:
RXN-8947
SABIO-RK:
7117
|
|
|
|
trans-4-hydroxy-L-proline <=> L-pyrroline-5-carboxylate + H2O + H+
|
4.2.1.172
trans-4-hydroxy-L-proline dehydratase
|
–
|
K
|
|
BRENDA:
BR52194
KEGG:
R11819
MetaCyc:
RXN-18502
|
|
|
|
H+ + H2O + L-pyrroline-5-carboxylate <=> L-glutamate_5-semialdehyde
|
0.0.0.0
|
–
|
BMK
|
|
BRENDA:
BR52883
KEGG:
R03314
MetaCyc:
SPONTPRO-RXN
|
|
|
|
L-pyrroline-5-carboxylate + NAD+ + H2O <=> H+ + L-glutamate + NADH
|
1.2.1.3
aldehyde dehydrogenase (NAD+)
1.2.1.88
L-glutamate gamma-semialdehyde dehydrogenase
|
–
–
|
K
|
|
BRENDA:
BS259182
KEGG:
R00707
MetaCyc:
PYRROLINECARBDEHYDROG-RXN
SABIO-RK:
1083;
15086
|
|
|
|
L-proline + FAD <=> L-pyrroline-5-carboxylate + FADH2
|
1.5
1.5.5.2
proline dehydrogenase
1.5.8
1.5.99.B2
|
–
–
–
–
|
BK
|
|
BRENDA:
BS389060
KEGG:
R10507
MetaCyc:
RXN-21556
|
|
|
|
ubiquinone + L-proline <=> ubiquinol + H+ + L-pyrroline-5-carboxylate
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
M
|
|
BRENDA:
BS426587
MetaCyc:
RXN0-7008
|
|
|
|
2-oxoglutarate + O2 + L-arginine + H+ <=> ethylene + CO2 + succinate + guanidine + L-pyrroline-5-carboxylate + H2O
|
1.13.12.19
2-oxoglutarate dioxygenase (ethene-forming)
1.14.11
1.14.20.7
2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
|
–
–
–
|
|
|
BRENDA:
BS440097
MetaCyc:
RXN-12535
|
|
|
|
L-proline + a_quinone <=> L-pyrroline-5-carboxylate + a_quinol
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
BK
|
|
BRENDA:
BR36918
KEGG:
R01253
|
|
|
|
Nomega-hydroxy-L-arginine <=> guanidine + L-pyrroline-5-carboxylate + H2O
|
1.14.20.7
2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
|
–
|
|
|
BRENDA:
BR49802
KEGG:
R10082
|
|
|
|
(2S,3S)-3-hydroxyarginine <=> H+ + guanidine + L-pyrroline-5-carboxylate + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-12536
|
|
|
|
electron-transfer_quinone + L-proline <=> electron-transfer_quinol + H+ + L-pyrroline-5-carboxylate
|
1.5.5.2
proline dehydrogenase
|
–
|
M
|
|
MetaCyc:
RXN-14903
|
|
|
|
S-adenosyl-L-methionine + L-pyrroline-5-carboxylate + L-arginine + ATP <=> peramine + S-adenosyl-L-homocysteine + AMP + diphosphate + H2O + H+
|
6.3.2
|
–
|
M
|
|
MetaCyc:
RXN-16089
|
|
|
|
L-pyrroline-5-carboxylate + e- + H+ <=> L-proline
|
not assigned
|
–
|
|
|
MetaCyc:
RXN0-7005
|
|
|
|
2-oxoadipate + L-arginine + O2 <=> Glutarate + CO2 + guanidine + L-pyrroline-5-carboxylate + H2O
|
1.14.20.7
2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
|
–
|
|
|
BRENDA:
BS442817
|
|
|
|
L-proline + menadione <=> L-pyrroline-5-carboxylate + menadiol
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS451692
|
|
|
|
L-proline + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O <=> L-pyrroline-5-carboxylate + reduced_iodonitrotetrazolium_chloride
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS397651
|
|
|
|
L-proline + 2,6-dichlorphenolindophenol <=> L-pyrroline-5-carboxylate + reduced_2,6-dichlorphenolindophenol
|
1.5.5.2
proline dehydrogenase
|
–
|
|
|
BRENDA:
BS441544
|
|
|
|
L-proline + H2O <=> L-pyrroline-5-carboxylate + H2O2
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS397650
|
|
|
|
L-proline + 2,6-dichlorophenolindophenol + H2O <=> L-pyrroline-5-carboxylate + reduced_2,6-dichlorophenolindophenol
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
|
|
BRENDA:
BS377069
|
|
|
|
L-proline + oxidized_2,6-dichlorophenolindophenol + H2O <=> L-pyrroline-5-carboxylate + reduced_2,6-dichlorophenolindophenol
|
1.5.99.B2
|
–
|
|
|
BRENDA:
BS428746
|
|
|
|
L-proline + ferricyanide + H2O <=> L-pyrroline-5-carboxylate + ferrocyanide
|
1.5.5.2
proline dehydrogenase
|
–
|
|
|
BRENDA:
BS377071
|
|
|
|
acetyl-CoA + L-pyrroline-5-carboxylate + H2O <=> CoA + N-acetyl-L-glutamate_5-semialdehyde
|
2.3.1.271
L-glutamate-5-semialdehyde N-acetyltransferase
|
–
|
|
|
BRENDA:
BS444201
|
|
|
|
methylmalonyl-CoA + L-pyrroline-5-carboxylate + H2O <=> CoA + (2S,5S)-6-methyl-5-carboxymethylproline + CO2
|
2.3.1.226
carboxymethylproline synthase
|
–
|
|
|
BRENDA:
BS423854
|
|
|
|
L-proline + acceptor <=> L-pyrroline-5-carboxylate + reduced_acceptor
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
B
|
|
BRENDA:
BR51015
|
|
|
|
L-proline + cytochrome_c + H2O <=> L-pyrroline-5-carboxylate + ferricytochrome_c
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
|
|
BRENDA:
BS397649
|
|
|
|
L-proline + oxidized_phenazine_methosulfate <=> L-pyrroline-5-carboxylate + reduced_phenazine_methosulfate
|
1.5.5.2
proline dehydrogenase
1.5.99.B2
|
–
–
|
|
|
BRENDA:
BS440304
|
|